Depressive disorders occur often jointly with anxiety disorders, which can cause serious health problems. The underlying mechanism is not fully understood. Figuring out the mechanism of depressive and anxiety disorders would benefit patients in future therapy. Brain-derived neurotrophic factor (BDNF) is a famous neurotrophin that modulates synaptic plasticity in the brain. It is generally believed that decreased BDNF levels are associated with depression. The purpose of this review is to elucidate the role of the BDNF-TrkB signaling pathway in different brain regions and its antidepressant effect, to provide scientific evidence for the treatment of anxiety and depression. The changes of the BDNF-TrkB signaling pathway before and after antidepressant treatment were compared by retrieving preclinical studies related to the BDNF-TrkB signaling pathway and classifying them according to different brain regions. It is found that the concentration of BDNF varies in different brain regions. The inhibition of the BDNF-TrkB pathway in the cortex, hippocampus, and amygdala and the activation of the BDNF-TrkB pathway in the anterior cingulate cortex (ACC), nucleus accumbens (NAc), and lateral habenula (LHb) is associated with anxiety and depression-like behaviors. Lacking BDNF or its receptor TrkB is not the cause of anxiety or depression, but affects the effect of antidepressant treatment. Increased BDNF can alleviate anxiety and depression. There are still other molecules that can regulate anxiety and depression-like behaviors by influencing the expression of BDNF or TrkB. The function of BDNF in the ACC, NAc, and LHb areas needs to be further explored.
| Published in | Clinical Neurology and Neuroscience (Volume 7, Issue 2) |
| DOI | 10.11648/j.cnn.20230702.11 |
| Page(s) | 18-30 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Depression, Anxiety, BDNF, TrkB, Mechanism, Pathway
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APA Style
Yafei Shi, Chunguang Mu, Yongjuan Xin. (2023). Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions. Clinical Neurology and Neuroscience, 7(2), 18-30. https://doi.org/10.11648/j.cnn.20230702.11
ACS Style
Yafei Shi; Chunguang Mu; Yongjuan Xin. Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions. Clin. Neurol. Neurosci. 2023, 7(2), 18-30. doi: 10.11648/j.cnn.20230702.11
AMA Style
Yafei Shi, Chunguang Mu, Yongjuan Xin. Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions. Clin Neurol Neurosci. 2023;7(2):18-30. doi: 10.11648/j.cnn.20230702.11
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Download@article{10.11648/j.cnn.20230702.11,
author = {Yafei Shi and Chunguang Mu and Yongjuan Xin},
title = {Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions},
journal = {Clinical Neurology and Neuroscience},
volume = {7},
number = {2},
pages = {18-30},
doi = {10.11648/j.cnn.20230702.11},
url = {https://doi.org/10.11648/j.cnn.20230702.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cnn.20230702.11},
abstract = {Depressive disorders occur often jointly with anxiety disorders, which can cause serious health problems. The underlying mechanism is not fully understood. Figuring out the mechanism of depressive and anxiety disorders would benefit patients in future therapy. Brain-derived neurotrophic factor (BDNF) is a famous neurotrophin that modulates synaptic plasticity in the brain. It is generally believed that decreased BDNF levels are associated with depression. The purpose of this review is to elucidate the role of the BDNF-TrkB signaling pathway in different brain regions and its antidepressant effect, to provide scientific evidence for the treatment of anxiety and depression. The changes of the BDNF-TrkB signaling pathway before and after antidepressant treatment were compared by retrieving preclinical studies related to the BDNF-TrkB signaling pathway and classifying them according to different brain regions. It is found that the concentration of BDNF varies in different brain regions. The inhibition of the BDNF-TrkB pathway in the cortex, hippocampus, and amygdala and the activation of the BDNF-TrkB pathway in the anterior cingulate cortex (ACC), nucleus accumbens (NAc), and lateral habenula (LHb) is associated with anxiety and depression-like behaviors. Lacking BDNF or its receptor TrkB is not the cause of anxiety or depression, but affects the effect of antidepressant treatment. Increased BDNF can alleviate anxiety and depression. There are still other molecules that can regulate anxiety and depression-like behaviors by influencing the expression of BDNF or TrkB. The function of BDNF in the ACC, NAc, and LHb areas needs to be further explored.},
year = {2023}
}
TY - JOUR T1 - Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions AU - Yafei Shi AU - Chunguang Mu AU - Yongjuan Xin Y1 - 2023/07/06 PY - 2023 N1 - https://doi.org/10.11648/j.cnn.20230702.11 DO - 10.11648/j.cnn.20230702.11 T2 - Clinical Neurology and Neuroscience JF - Clinical Neurology and Neuroscience JO - Clinical Neurology and Neuroscience SP - 18 EP - 30 PB - Science Publishing Group SN - 2578-8930 UR - https://doi.org/10.11648/j.cnn.20230702.11 AB - Depressive disorders occur often jointly with anxiety disorders, which can cause serious health problems. The underlying mechanism is not fully understood. Figuring out the mechanism of depressive and anxiety disorders would benefit patients in future therapy. Brain-derived neurotrophic factor (BDNF) is a famous neurotrophin that modulates synaptic plasticity in the brain. It is generally believed that decreased BDNF levels are associated with depression. The purpose of this review is to elucidate the role of the BDNF-TrkB signaling pathway in different brain regions and its antidepressant effect, to provide scientific evidence for the treatment of anxiety and depression. The changes of the BDNF-TrkB signaling pathway before and after antidepressant treatment were compared by retrieving preclinical studies related to the BDNF-TrkB signaling pathway and classifying them according to different brain regions. It is found that the concentration of BDNF varies in different brain regions. The inhibition of the BDNF-TrkB pathway in the cortex, hippocampus, and amygdala and the activation of the BDNF-TrkB pathway in the anterior cingulate cortex (ACC), nucleus accumbens (NAc), and lateral habenula (LHb) is associated with anxiety and depression-like behaviors. Lacking BDNF or its receptor TrkB is not the cause of anxiety or depression, but affects the effect of antidepressant treatment. Increased BDNF can alleviate anxiety and depression. There are still other molecules that can regulate anxiety and depression-like behaviors by influencing the expression of BDNF or TrkB. The function of BDNF in the ACC, NAc, and LHb areas needs to be further explored. VL - 7 IS - 2 ER -
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